Downregulation of PFTK1 Inhibits Migration and Invasion of Non-Small Cell Lung Cancer.

In summary, PFTK1 could significantly promote lung cancer metastasis through changing EMT progress and modulating intracellular cytoskeleton F-actin expression. Taken together, our findings indicated that PFTK1 might serve as a novel therapeutic target for the inhibition of NSCLC progression.