Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis.
Jérôme BohèreAlexandra Mancheno-FerrisSandy Al HayekJennifer ZanetPhilippe ValentiKohsuke AkinoYuya YamabeSachi InagakiHélène Chanut-DelalandeSerge PlazaYuji KageyamaDani OsmanCédric PoleselloFrançois PayrePublished in: Nature communications (2018)
To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) of Drosophila and required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult RNSCs further needs a post-translational processing mediated by the Polished rice (Pri) smORF peptides and impairing Svb function leads to RNSC apoptosis. We show that Svb interacts both genetically and physically with Yorkie (YAP/TAZ in vertebrates), a nuclear effector of the Hippo pathway, to activate the expression of the inhibitor of apoptosis DIAP1. These data therefore identify Svb as a nuclear effector in the Hippo pathway, critical for the survival of adult somatic stem cells.
Keyphrases
- stem cells
- cell death
- cell cycle arrest
- oxidative stress
- endoplasmic reticulum stress
- transcription factor
- cell therapy
- poor prognosis
- childhood cancer
- dendritic cells
- regulatory t cells
- binding protein
- bone marrow
- immune response
- big data
- pi k akt
- electronic health record
- gene expression
- long non coding rna
- artificial intelligence
- dna methylation
- machine learning
- dna binding
- signaling pathway
- type iii