Functional relationship between CFTR and RAC3 expression for maintaining cancer cell stemness in human colorectal cancer.
Alejandra Graciela PalmaMileni Soares MachadoMaría Cecilia LiraFrancisco RosaMaría Fernanda RubioGabriela MarinoBasilio Aristidis KotsiasMónica Alejandra CostasPublished in: Cellular oncology (Dordrecht) (2021)
CFTR may play a non-tumor suppressor role in colorectal cancer development and maintenance involving enhancement of the expression of a set of genes related to cancer stemness and development in patients without CFTR mutations.
Keyphrases
- cystic fibrosis
- poor prognosis
- end stage renal disease
- stem cells
- epithelial mesenchymal transition
- ejection fraction
- chronic kidney disease
- endothelial cells
- newly diagnosed
- peritoneal dialysis
- binding protein
- genome wide
- prognostic factors
- patient reported outcomes
- squamous cell
- cancer stem cells
- transcription factor