Betaine-homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling.

Chuchu LiuYao ZhangYanping WangNing WangJunting XuXingxing LiangJie XiongSijia LuPeihui ZhouWeiping Jia Suzhen Chen

Published in: Obesity (Silver Spring, Md.) (2023)

The findings of this study highlight the obesogenic and diabetogenic role of adipocytic Bhmt and propose Bhmt as a promising therapeutic target for obesity and obesity-related diabetes.

Keyphrases

insulin resistance
type diabetes
high fat diet induced
metabolic syndrome
adipose tissue
skeletal muscle
high fat diet
polycystic ovary syndrome
glycemic control
cardiovascular disease
weight loss
epithelial mesenchymal transition
weight gain
transforming growth factor
physical activity
fatty acid