The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.
Biao XuMengna ZhangXuerui ShiRun ZhangDan ChenYong ChenZilong WangYu QiuTing ZhangKangtai XuXiaoyu ZhangWolfgang LiedtkeRui WangQuan FangPublished in: British journal of pharmacology (2019)
DN-9 produces potent analgesia with minimal side effects, which strengthen the candidacy of peripherally acting opioids with multifunctional agonistic properties to enter human studies to alleviate the current highly problematic misuse of classic opioids on a large scale.