PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice.

Mouin NasrAlexis FayAdrien LupieriNicole MaletAnne DarmonRana ZahreddineAudrey SwiaderAmandine WahartJulien ViaudAnne Nègre-Salvayre Emilio Hirsch Daniel Monteyne David Perez-Morga Nicolas Dupont Patrice Codogno Damien Ramel Etienne Morel Muriel Laffargue Stéphanie Gayral

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our data reveal that mechanical forces variability within the arterial system determines EC autophagic response and supports a central role of PI3KCIIα/mTORC1 axis to prevent EC dysfunction in LSS regions.

Keyphrases

cell death
oxidative stress
electronic health record
high fat diet induced
cardiovascular disease
quality improvement
endoplasmic reticulum stress
genome wide
signaling pathway
big data
single cell
type diabetes
gene expression
insulin resistance
adipose tissue