Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma.

Gorkem Odabas Metin CetinSerdar TurhalHuseyin BalogluA Emre SayanTamer Yagci

Published in: Canadian journal of gastroenterology & hepatology (2018)

Plexin C1 distinguishes HCC cells of epithelial characteristics from those with the mesenchymal phenotype. Compared to the nontumoral liver, HCC tissues significantly overexpress Plexin C1. The newly generated PE4 antibody can be evaluated in larger HCC cohorts and might be exploited for the examination of Plexin C1 expression pattern in other epithelial malignancies.

Keyphrases

induced apoptosis
poor prognosis
stem cells
gene expression
cell cycle arrest
bone marrow
oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
long non coding rna
pi k akt