Validation of Microsatellite Instability Detection Using a Comprehensive Plasma-Based Genotyping Panel.
Jason WillisMartina I LefterovaAlexander ArtyomenkoPashtoon Murtaza KasiYoshiaki NakamuraKabir ModyDaniel V T CatenacciMarwan FakihCatalin BarbacioruJing ZhaoMarcin SikoraStephen R FaircloughHyuk LeeKyoung-Mee KimJinchul KimDanielle GavinoManuel BenavidesNir PeledTimmy NguyenMike CusnirRamez N EskanderGeorges AzziTakayuki YoshinoKimberly C BanksVictoria M RaymondRichard B LanmanDarya I ChudovaAmirAli TalasazScott KopetzJeeyun LeeJustin I OdegaardPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
cfDNA-based MSI detection using Guardant360 is highly concordant with tissue-based testing, enabling highly accurate detection of MSI status concurrent with comprehensive genomic profiling and expanding access to immunotherapy for patients with advanced cancer for whom current testing practices are inadequate.See related commentary by Wang and Ajani, p. 6887.