Differential Effects of Trp53 Alterations in Murine Colorectal Cancer.
Alexander M BetzlerLahiri Kanth NanduriBarbara HissaLinda BlickensdörferMichael H MudersJanine RoyMoritz JesinghausKatja SteigerWilko WeichertMatthias KloorBarbara KlinkMichael SchroederMassimiliano MazzoneJürgen WeitzChristoph ReissfelderNuh N RahbariSebastian SchölchPublished in: Cancers (2021)
This model realistically mimics human CRC in many aspects, allows new insights into the role of TP53 in CRC, enables highly predictive preclinical studies and demonstrates the value of GEMMs in current translational cancer research and drug development.