Norisoboldine, a Natural Alkaloid from Lindera aggregata (Sims) Kosterm, Promotes Osteogenic Differentiation via S6K1 Signaling Pathway and Prevents Bone Loss in OVX Mice.
Shiming LiWenliang YanKainong SunJingyuan MiaoZichao LiuJiayang XuXiaoyu WangBo LiQian ZhangPublished in: Molecular nutrition & food research (2024)
NOR effects in enhancing osteoblast-induced bone formation via S6K1 pathway, suggesting the potential of NOR in osteoporosis treatment by increasing bone formation.
Keyphrases
- bone loss
- signaling pathway
- mesenchymal stem cells
- high glucose
- postmenopausal women
- bone marrow
- diabetic rats
- pi k akt
- bone mineral density
- epithelial mesenchymal transition
- high fat diet induced
- mouse model
- endothelial cells
- type diabetes
- induced apoptosis
- endoplasmic reticulum stress
- replacement therapy
- wild type