Association between congenital heart disease and NKX2.5 gene polymorphisms: systematic review and meta-analysis.
Thelma Beatríz González-CastroCarlos Alfonso Tovilla-ZárateMaría Lilia López-NarváezIsela Esther Juárez-RojopJuan Calderón-ColmeneroJuan Pablo SandovalJosé A García-MontesRuben Blachman-BraunRosa Giannina Castillo-AvilaEsbeidy García-FloresBenny G Cazarín-SantosVerónica Marusa Borgonio-CuadraRosalinda Posadas-SánchezGilberto Vargas-AlarconJosé-Manuel Rodríguez-PérezNonanzit Pérez-HernándezPublished in: Biomarkers in medicine (2021)
Aim: To analyze the association of NKX2.5 gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. Materials & methods: PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between NKX2.5 gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. Results: We observed that the allelic model of rs703752 and rs2277923 increased the risk in the overall population: OR = 1.24; 95% CI: 1.00-1.55; Z p-value = 0.049; OR = 1.18; 95% CI: 0.01-1.37; Z p-value = 0.036; respectively. Conclusion: Our results suggested that the rs703752 and rs2277923 polymorphisms of the NKX2.5 gene are associated with CHD.