Protocol-Stipulated Dose Modification to Manage Chemotherapy-Induced Peripheral Neuropathy in Children, Adolescents, and Young Adults With High-Risk Hodgkin Lymphoma.
Mallorie B HeneghanSusan K ParsonsFrank G KellerLindsay A RenfroQinglin PeiAngie Mae RoddayYue WuAngela PunnettJennifer A BelskyTara O HendersonKara M KellySharon M CastellinoPublished in: JCO oncology practice (2024)
A staged dose modification plan for vinca alkaloids and BV as administered in AHOD1331 minimized the effect of incorporating a second microtubulin inhibitor on CIPN without compromising treatment efficacy in the BV arm.