CENPA knockdown restrains cell progression and tumor growth in breast cancer by reducing PLA2R1 promoter methylation and modulating PLA2R1/HHEX axis.

Gang WuZhongkai FanXin Li

Published in: Cellular and molecular life sciences : CMLS (2024)

CENPA knockdown restrained breast cancer cell proliferation and migration and attenuated tumor growth in vivo through reducing PLA2R1 promoter methylation and increasing PLA2R1 and HHEX expression. We may provide a promising prognostic biomarker and novel therapeutic target for breast cancer.

Keyphrases

dna methylation
genome wide
gene expression
transcription factor
poor prognosis
single cell
signaling pathway
stem cells
mesenchymal stem cells
young adults
breast cancer risk