Decreased expression of ATP-binding cassette protein G1 promotes abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis.

Xinyu KangQian LiuYuqian ShiHelin WangHongyun ZhangTao YeJing ZhangFeng HeMian Zhang

Published in: Journal of oral rehabilitation (2023)

Abnormal adipogenesis of chondrocytes and decreased ABCG1 expression were observed in degenerative cartilage of TMJ OA. ABCG1 overexpression effectively inhibits the adipogenesis of chondrocytes and thus alleviates TMJ condylar cartilage degeneration.

Keyphrases

extracellular matrix
poor prognosis
binding protein
high fat diet induced
knee osteoarthritis
rheumatoid arthritis
long non coding rna
type diabetes
transcription factor
mouse model
metabolic syndrome
skeletal muscle
adipose tissue