Correlating somatic copy number alteration in aqueous humour cfDNA with chemotherapy history, eye salvage and pathological features in retinoblastoma.

Yingxiu LuoMingpeng XuLudi YangYiran YaoJesse L BerryLiya XuXuyang WenXiaoyu HeMinglei HanXianqun FanXianqun Fan Renbing Jia

Published in: The British journal of ophthalmology (2023)

Sequencing of AH cfDNA in RB can provide sufficient in vivo information. 19q loss was a potential signature of advanced cases clinically and pathologically.Repeated sampling from eyes receiving sequential chemotherapy should be conducted to evaluate fluctuation of SCNA in future study.

Keyphrases

copy number
mitochondrial dna
genome wide
locally advanced
dna methylation
optical coherence tomography
squamous cell carcinoma
single cell
gene expression
health information
social media
human health