Manganese-Catalyzed N-F Bond Activation for Hydroamination and Carboamination of Alkenes.

Yun-Xing JiJinxia LiChun-Min LiShuanglin Qu Bo Zhang

Published in: Organic letters (2020)

A visible-light-promoted method for generating amidyl radicals from N-fluorosulfonamides via a manganese-catalyzed N-F bond activation strategy is reported. This protocol employs a simple manganese complex, Mn2(CO)10, as the precatalyst and a cheap silane, (MeO)3SiH, as both the hydrogen-atom donor and the F-atom acceptor, enabling intramolecular/intermolecular hydroaminations of alkenes, two-component carboamination of alkenes, and even three-component carboamination of alkenes. A wide range of valuable aliphatic sulfonamides can be readily prepared using these practical reactions.

Keyphrases

visible light
room temperature
energy transfer
molecular dynamics
electron transfer
randomized controlled trial
transition metal
mass spectrometry
solid phase extraction