Gene expression profiling and multiplex immunofluorescence analysis of bullous pemphigoid immune-related adverse event reveal upregulation of toll-like receptor 4/complement-induced innate immune response and increased density of T H 1 T-cells.
Mario L Marques-PiubelliRiyad N H SeervaiKumaran M MudaliarWencai MaDenái R MiltonJing WangAaron MuhlbauerEdwin R ParraLuisa M SolisPriyardhisini NagarajanJodi J SpeiserCourtney HudgensWoo Cheal ChoLeomar Y BallesterAnisha PatelOmar PachaKelly C NelsonMichael T TetzlaffRodabe N AmariaCarlos A Torres-CabalaVictor G PrietoIgnacio I WistubaJonathan L CurryPublished in: Journal of cutaneous pathology (2023)
1 immune cell polarization and decreased Tregs in the blister floor. TLR/complement signaling may underlie the immunopathogenesis of BP-irAE.