Tenacissoside H Induces Apoptosis and Inhibits Migration of Colon Cancer Cells by Downregulating Expression of GOLPH3 Gene.

Zhong-Shi Hong Hai-Bin Zhuang Cheng-Zhi Qiu Ze-Sheng Shi Chun-Xiao Wang Zhi-Chuan ChenJian-Peng Pan

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

Collectively, the present results indicated that TDH can inhibit the proliferation vitality of colon cancer LoVo cells through downregulating GOLPH3 expression and activity of PI3K/AKT/mTOR and Wnt/β-catenin signaling pathways.

Keyphrases

poor prognosis
signaling pathway
induced apoptosis
cell proliferation
epithelial mesenchymal transition
cell cycle arrest
long non coding rna
copy number
oxidative stress
cell death