Neuroserpin normalization by mesenchymal stem cell therapy after encephalopathy of prematurity in neonatal rats.
Lan-Wan WangChien-Wei HsiungChing-Ping ChangMao-Tsun LinShyi-Jou ChenPublished in: Pediatric research (2024)
Neuroserpin is secreted by subplate neurons and may regulate the development of neurons and oligodendrocyte-axon contact for myelination in the premature brain. LPS-sensitized hypoxic-ischemia/reperfusion (LHIR) injury caused the developmental disturbances of neurons/axons and oligodendrocytes, and lowered neuroserpin levels in a neonatal rat model simulating encephalopathy of prematurity. Mesenchymal stem cell therapy alleviated the developmental disturbances after LHIR injury through protection of neuroserpin expression in subplate neurons, offering a new perspective on potential treatment for encephalopathy of prematurity.
Keyphrases
- cell therapy
- stem cells
- spinal cord
- preterm infants
- mesenchymal stem cells
- early onset
- low birth weight
- bone marrow
- poor prognosis
- inflammatory response
- spinal cord injury
- resting state
- multiple sclerosis
- functional connectivity
- risk assessment
- long non coding rna
- brain injury
- smoking cessation
- human health
- climate change
- cerebral ischemia