Modelling Alzheimer's disease in a dish: dissecting amyloid-β metabolism in human neurons.

Published in: Neuronal signaling (2024)

This scientific commentary refers to 'Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition' by Rowland et al. (https://doi.org/10.1042/NS20230016). Insulin-degrading enzyme (IDE) and neprilysin (NEP) have been proposed as two Aβ-degrading enzymes supported by human genetics and in vivo data. Rowland et al. provide complementary evidence of a key role for IDE in Aβ metabolism in human-induced pluripotent stem cell (iPSC)-derived cortical neurons.

Keyphrases

endothelial cells
induced pluripotent stem cells
stem cells
type diabetes
pluripotent stem cells
spinal cord
mesenchymal stem cells
machine learning
cognitive decline
metabolic syndrome
electronic health record
zika virus
mild cognitive impairment
bone marrow
deep learning