Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study.
Rachel Katherine CrowleyConor P WoodsBeverly A HughesJoanna GrayTheresa McCarthyAngela E TaylorLaura L GathercoleCedric H L ShackletonNicola CrabtreeWiebke ArltPaul M StewartJeremy W TomlinsonPublished in: Clinical endocrinology (2019)
Longitudinal deterioration in metabolic phenotype is not associated with increased 11β-HSD1 activity, but decreased subcutaneous adipose tissue gene expression. These changes may represent a compensatory mechanism to decrease local glucocorticoid exposure in the face of an adverse metabolic phenotype.