Human Placenta-Derived Mesenchymal Stem Cells Ameliorate Diabetic Neuropathy via Wnt Signaling Pathway.
Songsong PanSushant S HadaYang LiuChao HuMengdie ZhouShaoqiu ZhengMinjie XuChangsheng ShiShiwu YinXiaoyun XiePublished in: Stem cells international (2022)
PMSCs improved the symptoms of diabetic peripheral neuropathy, along with the improvement of nerve myelin lesions, promotion of nerve regeneration, and activation of Schwann cells, which might be related to the regulation of Wnt signaling pathway and inhibition of apoptosis.
Keyphrases
- cell cycle arrest
- pi k akt
- signaling pathway
- induced apoptosis
- cell proliferation
- stem cells
- peripheral nerve
- endoplasmic reticulum stress
- wound healing
- type diabetes
- oxidative stress
- endothelial cells
- cell death
- epithelial mesenchymal transition
- induced pluripotent stem cells
- white matter
- physical activity
- pluripotent stem cells
- sleep quality