HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET.

Tongyue ZhangYijun WangMeng XieXiaoyu JiXiangyuan LuoXiaoping ChenBixiang ZhangDanfei LiuYangyang FengMengyu SunWenjie HuangLimin Xia

Published in: Journal of experimental & clinical cancer research : CR (2022)

This study uncovers functional and prognostic roles for ETV1 in HCC and exposes a positive feedback loop of HGF-ERK1/2-ETV1-c-MET. Targeting this pathway may provide a potential therapeutic intervention for ETV1-overexpressing HCC.

Keyphrases

acute lymphoblastic leukemia
randomized controlled trial
tyrosine kinase
signaling pathway
transcription factor
cancer therapy
drug delivery