Our findings indicate the involvement of dysregulated TET2 expression in neovascularization by regulating the promoter methylation and transcription of downstream genes (notably ECM1), eventually leading to PDR. The TET2-induced hypomethylation of downstream gene promoters represents a potential therapeutic target and offers a novel perspective on the mechanism underlying neovascularization in PDR.
Keyphrases
- diabetic retinopathy
- genome wide
- dna methylation
- optical coherence tomography
- transcription factor
- genome wide identification
- poor prognosis
- extracellular matrix
- high glucose
- gene expression
- copy number
- vascular endothelial growth factor
- diabetic rats
- drug induced
- genome wide analysis
- binding protein
- human health
- climate change
- endothelial cells
- bioinformatics analysis