Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology.

Nils Ole Dalby Christina Birkedahl Falk-Petersen Ulrike Leurs Petra Scholze Jacob Krall Bente Frølund Petrine Wellendorph

Published in: British journal of pharmacology (2020)

Kinase activity infers spontaneous gating in α4 β1/3 δ receptors in DGGCs. This significantly limits the efficacy of GABAA agonists and has implications in pathologies involving aberrant excitability caused by phosphorylation (e.g. addiction and epilepsy). In such cases, the efficacy of δ-preferring GABAA ligands may be reduced.

Keyphrases

induced apoptosis
protein kinase
cell cycle arrest
cell death
cell proliferation
working memory