Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the "ESKAPE" pathogen Pseudomonas aeruginosa .
Kira L F HiltonHoward TolleyJosé Luis Ortega-RoldanGary S ThompsonJ Mark SuttonCharlotte K HindJennifer R HiscockPublished in: Chemical communications (Cambridge, England) (2023)
We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa . Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.