Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin.

Camille LaporteEmily TubbsJustine CristanteAnne-Sophie GauchezSandra PesentiFrédéric LamarcheCécile Cottet-RousselleCatherine GarrelAnaick MoisanJean-Marc MoulisEric FontainePierre-Yves BenhamouSandrine Lablanche

Published in: Stem cell research & therapy (2019)

Our data evidenced that MSCs are able to preserve islet insulin secretion through a modulation of the oxidative imbalance mediated by heme and iron via heme oxygenase-1 and ferritin in a context of cytokine exposure.

Keyphrases

mesenchymal stem cells
umbilical cord
iron deficiency
endothelial cells
bone marrow
electronic health record
poor prognosis
induced pluripotent stem cells
cell proliferation
oxidative stress
big data
long non coding rna
artificial intelligence
deep learning
data analysis