A model mimicking catabolic inflammatory disease; a controlled randomized study in humans.

Maike MoseNikolaj RittigUlla Ramer MikkelsenNiels JessenMads Bisgaard BengtsenBrit ChristensenJens Otto Lunde JørgensenNiels Møller

Published in: PloS one (2020)

We found that combined systemic inflammation, fasting and bed rest induced marked insulin resistance and increased energy expenditure and lipolysis, rendering this controlled experimental model suitable for anti-catabolic intervention studies, mimicking clinical conditions.

Keyphrases

insulin resistance
adipose tissue
randomized controlled trial
metabolic syndrome
high fat diet
high glucose
diabetic rats
oxidative stress
type diabetes
polycystic ovary syndrome
blood glucose
high fat diet induced
drug induced
blood pressure
weight loss