The NAv1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing.

Jose Vicente Torres-PérezPavel AdamekJiri PalecekMarcela VizcaychipiIstvan NagyAngelika Varga

Published in: Journal of molecular medicine (Berlin, Germany) (2017)

• Burn injury upregulates Nav1.7 expression in primary sensory neurons. • Burn injury results in increased activity of Nav1.7-expressing primary sensory neurons. • Inhibiting Nav1.7 by protoxin II reduces spinal nociceptive processing. • Nav1.7 represents a potential target to reduce pain in burn injury.

Keyphrases

spinal cord
neuropathic pain
wound healing
poor prognosis
chronic pain
signaling pathway
pain management
risk assessment
high glucose
climate change
long non coding rna
diabetic rats