Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis.

Hongjuan YouNing ZhangTong YuLihong MaQi LiXing WangDongchen YuanDelong KongXiangye LiuWei HuDongsheng LiuFanyun KongKuiyang ZhengRen-Xian Tang

Published in: British journal of cancer (2023)

HBX enhances the stability of GRP78 through TRIM25 to increase the expression of MAN1B1 to facilitate tumorigenesis, and we provide new insights into the molecular mechanisms underlying HBV-induced malignancy.

Keyphrases

hepatitis b virus
poor prognosis
liver failure
binding protein
endoplasmic reticulum stress
diabetic rats
high glucose
oxidative stress
single molecule
amino acid
small molecule