An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function.
Andrew I MorrisonAleksandra M MikulaSander W SpiekstraMichael de KokAlsya A AffandiHenk P RoestLuc J W van der LaanCharlotte M de WindeJasper J KoningSusan GibbsReina E MebiusPublished in: Tissue engineering and regenerative medicine (2023)
This 3D FRC-DC organotypic model highlights the influence and importance of FRCs for DC functioning in a more realistic HuLN microenvironment. As such, this work provides a starting point for the development of an in vitro HuLN.