Carer preferences of route of administration of transmucosal diamorphine and willingness to take part in a randomised controlled trial: an interview study (DIPPER).
Liz JamiesonEmily HarropChristina LiossiKatherine BoyceLorraine MitchellMargaret JohnsonYogini H JaniVictoria AkinyooyeSimon S SkeneIan Chi Kei Ck WongRichard F HowardKate OultonPublished in: BMC palliative care (2022)
A randomised controlled trial of oral morphine versus transmucosal diamorphine would need to consider trial logistics, especially time commitment. Parents felt that the trial should be introduced initially by the clinical team, with written information from the research team, and sufficient time to ask questions. Patients who had discontinued oral morphine because of side effects, or those with gastrointestinal failure, should be excluded. Maintaining stability in pain management was essential to families, so the timing of the trial is a potential issue.