Comparative Study of Porous Iron Foams for Biodegradable Implants: Structural Analysis and In Vitro Assessment.
Gabriela GąsiorMarlena GrodzickaTomasz JędrzejewskiWiśniewski MarekAleksandra RadtkePublished in: Journal of functional biomaterials (2023)
Biodegradable metal systems are the future of modern implantology. This publication describes the preparation of porous iron-based materials using a simple, affordable replica method on a polymeric template. We obtained two iron-based materials with different pore sizes for potential application in cardiac surgery implants. The materials were compared in terms of their corrosion rate (using immersion and electrochemical methods) and their cytotoxic activity (indirect test on three cell lines: mouse L929 fibroblasts, human aortic smooth muscle cells (HAMSC), and human umbilical vein endothelial cells (HUVEC)). Our research proved that the material being too porous might have a toxic effect on cell lines due to rapid corrosion.
Keyphrases
- endothelial cells
- drug delivery
- cardiac surgery
- molecularly imprinted
- metal organic framework
- iron deficiency
- highly efficient
- tissue engineering
- gold nanoparticles
- aortic valve
- high glucose
- soft tissue
- current status
- left ventricular
- molecular dynamics simulations
- extracellular matrix
- heart failure
- ionic liquid
- pulmonary artery
- vascular endothelial growth factor
- risk assessment
- human health
- climate change
- quantum dots
- pulmonary arterial hypertension
- sensitive detection
- lactic acid