A first-in-human phase I study of TAS-117, an allosteric AKT inhibitor, in patients with advanced solid tumors.

Toshihiko DoiShunji TakahashiDaisuke AokiKan YonemoriHiroki HaraKosei HasegawaKazuhiro TakeharaKenichi HaranoMayu YunokawaHiroyuki NomuraTatsunori ShimoiKoji HorieAiko OgasawaraShinichi Okame

Published in: Cancer chemotherapy and pharmacology (2024)

jRCT2080222728 (January 29, 2015).

Keyphrases

endothelial cells
small molecule
signaling pathway
cell proliferation
pluripotent stem cells