Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric Myocardium.

Shatha SalamehDevon GuerrelliJacob A MillerManan DesaiNicolae MoiseCan YerebakanAlisa BrucePranava SinhaYves d'UdekemSeth H WeinbergNikki Gillum Posnack

Published in: bioRxiv : the preprint server for biology (2024)

This study provides valuable insights into age-dependent changes in human cardiac gene expression and electrophysiology among patients with CHD, shedding light on molecular mechanisms underlying cardiac development and function across different developmental stages.

Keyphrases

gene expression
endothelial cells
single cell
induced pluripotent stem cells
left ventricular
pluripotent stem cells
atrial fibrillation