Immunoassay-Amplified Responses Using a Functionalized MoS2-Based SPR Biosensor to Detect PAPP-A2 in Maternal Serum Samples to Screen for Fetal Down's Syndrome.
Nan-Fu ChiuMing-Jung TaiDevi Taufiq NurrohmanTing-Li LinYing-Hao WangChen-Yu ChenPublished in: International journal of nanomedicine (2021)
Carboxyl-MoS2-based SPR biosensors can be used as a new diagnostic technology to respond to the increasing need for fetal Down's syndrome screening in maternal serum samples. Our results demonstrated that the carboxyl-MoS2-based SPR biosensor was capable of determining PAPP-A2 levels with acceptable accuracy and recovery. We hope that this technology will be investigated in diverse clinical trials and in real case applications for screening and early diagnosis in the future.
Keyphrases
- quantum dots
- sensitive detection
- clinical trial
- label free
- birth weight
- room temperature
- gold nanoparticles
- case report
- reduced graphene oxide
- high throughput
- current status
- randomized controlled trial
- atomic force microscopy
- mass spectrometry
- single cell
- physical activity
- liquid chromatography
- phase iii
- placebo controlled