A comprehensive profiling of the immune microenvironment of breast cancer brain metastases.

Gaia GriguoloAnna TosiMaria Vittoria DieciSusan FinebergValentina RossiAnnavera VenturaMichele BottossoLuc BauchetFederica MigliettaJack JacobValerie RigauMatteo FassanWilliam JacotPierFranco Conte Antonio RosatoAmelie DarlixValentina Guarneri

Published in: Neuro-oncology (2022)

Our results highlight subtype-related differences in BCBM immune microenvironment and identify two potential therapeutic targets, M2 microglia/macrophage polarization in HER2- and PD-1/PD-L1 interaction in HER2+ BCBMs, which warrant future exploration in clinical trials.

Keyphrases

brain metastases
clinical trial
small cell lung cancer
stem cells
inflammatory response
current status
neuropathic pain
randomized controlled trial
climate change
phase ii