Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation.
Dandan JiaHuijie ZhangTiemin LiuRu WangPublished in: Metabolites (2024)
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. This review comprehensively summarizes the benefits of regular exercise in addressing the age-related decline in adipose tissue function. Utilizing relevant examples of this approach, we address the possibility of designing therapeutic interventions based on these molecular mechanisms.
Keyphrases
- adipose tissue
- insulin resistance
- high intensity
- oxidative stress
- high fat diet
- physical activity
- resistance training
- healthcare
- randomized controlled trial
- public health
- dna damage
- type diabetes
- mental health
- endothelial cells
- induced apoptosis
- single cell
- blood pressure
- body mass index
- social media
- climate change
- ischemia reperfusion injury
- weight loss
- cell therapy
- diabetic rats
- glycemic control