Role of Adult Tissue-Derived Pluripotent Stem Cells in Bone Regeneration.

Liudmila Leppik Katarzyna SielatyckaD HenrichZhihua Han H Wang Maria José Eischen-Loges Karla Mychellyne Costa Oliveira Mit Balvantray BhavsarM Z RatajczakJohn Howard Barker

Published in: Stem cell reviews and reports (2020)

Based on the results, we can conclude that VSEL play a role in BM-MNC induced bone formation. In our rat femur defect model, in defects treated with VSEL-depleted BM-MNC, osteoclastogenesis and bone formation were decreased, and foreign body reaction was increased.

Keyphrases

bone regeneration
pluripotent stem cells
high glucose
diabetic rats
oxidative stress
bone mineral density
drug induced
bone loss
body composition
young adults
inflammatory response
childhood cancer
finite element
stress induced
total hip arthroplasty