Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis.

Elizabeth CostelloSarah RockNikos StratakisSandrah P EckelDouglas I WalkerDamaskini ValviDora CserbikTodd JenkinsStavra A XanthakosRohit KohliStephanie SisleyVasilis VasiliouMichele A La MerrillHugo RosenDavid V ContiRob McConnellLeda Chatzi

Published in: Environmental health perspectives (2022)

There is consistent evidence for PFAS hepatotoxicity from rodent studies, supported by associations of PFAS and markers of liver function in observational human studies. This review identifies a need for additional research evaluating next-generation PFAS, mixtures, and early life exposures. https://doi.org/10.1289/EHP10092.

Keyphrases

liver injury
drug induced
early life
endothelial cells
case control
genome wide
air pollution
ionic liquid
induced pluripotent stem cells
pluripotent stem cells
dna methylation