Neurobiological effects of gallic acid: current perspectives.
Md Shimul BhuiaMd Mizanur RahamanTawhida IslamMehedi Hasan BappiMd Iqbal SikderKazi Nadim HossainFatama AkterAbdullah Al Shamsh ProttayMd RokonuzzmanEda Sönmez GürerDaniela CalinaMuhammad Torequl IslamJavad Sharifi RadPublished in: Chinese medicine (2023)
Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer's disease, Parkinson's disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.
Keyphrases
- pet ct
- neuropathic pain
- public health
- big data
- spinal cord
- healthcare
- spinal cord injury
- cerebral ischemia
- systematic review
- electronic health record
- adverse drug
- mental health
- oxidative stress
- sleep quality
- randomized controlled trial
- emergency department
- human health
- physical activity
- cognitive impairment
- social media
- blood brain barrier
- subarachnoid hemorrhage
- inflammatory response
- health promotion