Treatment of COPD with Long-Acting Bronchodilators: Association Between Early and Longer-Term Clinically Important Improvement.
Claus F VogelmeierIan P NayaFrancois MaltaisBjermer LeifEdward M KerwinLee TombsPaul W JonesChris ComptonDavid A LipsonIsabelle H BoucotPublished in: International journal of chronic obstructive pulmonary disease (2021)
Achieving a CII at Week 4 was associated with longer-term improvement in PROs and a reduced risk of deterioration. Further research is required to investigate the importance of an early response to treatment on the long-term disease course.