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Relay Catalysis for Selective Aerobic Oxidative Esterification of Primary Alcohols with Methanol.

Yibo YuJie LinAnni QinHuanan WangJie WangWeiyi WangGuolin WuQian ZhangHui QianShengming Ma
Published in: Organic letters (2024)
Esters are bulk and fine chemicals and ubiquitous in polymers, bioactive compounds, and natural products. Their traditional synthetic approach is the esterification of carboxylic acids or their activated derivatives with alcohols. Herein, a bimetallic relay catalytic protocol was developed for the aerobic esterification of one alcohol in the presence of a slowly oxidizing alcohol, which has been identified as methanol. A concise synthesis of phlomic acid was executed to demonstrate the practicality and potential of this reaction.
Keyphrases
  • high intensity
  • carbon dioxide
  • alcohol consumption
  • randomized controlled trial
  • air pollution
  • risk assessment
  • crystal structure