Allogeneic human umbilical cord Wharton's jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo.
Hao Daniel LinChui-Yee FongArijit BiswasAriff BongsoPublished in: Stem cell research & therapy (2020)
In this report, we confirmed that allogeneic hWJSCs provide an attractive platform for the ex vivo expansion of high fold numbers of UCB CD34+ cells while keeping them primitive. Allogeneic hWJSCs are readily available in abundance from discarded UCs, can be easily frozen in cord blood banks, thawed, and then used as a platform for UCB-HSC expansion if numbers are inadequate.
Keyphrases
- cord blood
- stem cell transplantation
- umbilical cord
- induced apoptosis
- stem cells
- mesenchymal stem cells
- endothelial cells
- bone marrow
- cell cycle arrest
- hematopoietic stem cell
- high throughput
- induced pluripotent stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- oxidative stress
- signaling pathway
- cell death
- microbial community
- wastewater treatment