YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.

Xiumei LiuDi ChenHuan ChenWen WangYu LiuYawei WangChao DuanZhen NingXin GuoWuxiyar OtkurJing LiuHuan QiXiaolong LiuAifu LinTian XiaHong-Xu LiuHai-Long Piao

Published in: Cancer communications (London, England) (2021)

This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b-ZEB1 axis in HCC cells. Furthermore, these results highlight that YB1 may play biological functions via miRNAs-mediated gene regulation, and it can serve as a potential therapeutic target in human cancers.

Keyphrases

epithelial mesenchymal transition
energy transfer
induced apoptosis
long non coding rna
endothelial cells
signaling pathway
papillary thyroid
cell cycle arrest
squamous cell carcinoma
pluripotent stem cells
childhood cancer
cell death
quantum dots