Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors.

Jonathan CheeMark W WatsonAbha ChopraBella NguyenAlistair M CookJenette CreaneyWillem J LesterhuisBruce W RobinsonY C Gary LeeAnna K NowakRichard A LakeAlison M McDonnell

Published in: BMC research notes (2018)

Both CD8+ and CD4+ T cells from effusion showed increased expression of T cell inhibitory receptors PD-1, LAG-3 and Tim-3 compared to blood. Comprehensive T cell receptor sequencing on one of the patients showed a discordant distribution of clonotypes in the antigen-experienced (PD-1+) compartment between effusion and blood, suggesting an enrichment of antigen specific clonotypes in the effusion, with potential as an immunological response biomarker.

Keyphrases

end stage renal disease
newly diagnosed
poor prognosis
peritoneal dialysis
prognostic factors
binding protein
nk cells
long non coding rna
human health
patient reported