Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome.

Chunliu MiZhe WangMing Yue LiZhi Hong ZhangJuan MaXuejun Jin

Published in: British journal of pharmacology (2018)

Our research describes a mechanism by which ZFP91 promotes production of IL-1β under physiological conditions and suggests that ZFP91 may be a promising therapeutic target for intervention in inflammatory, infectious and autoimmune-related diseases.

Keyphrases

randomized controlled trial
cell death
multiple sclerosis
oxidative stress
induced apoptosis
drug induced
amino acid
protein protein
oxide nanoparticles
signaling pathway