Registration-based biomarkers for neoadjuvant treatment response of pancreatic cancer via longitudinal image registration.

Jon S HeiselmanBrett L EckerLiana Langdon-EmbryEileen M O'ReillyMichael I MigaWilliam R JarnaginRichard Kinh Gian DoNatally HorvatAlice C WeiJayasree Chakraborty

Published in: Journal of medical imaging (Bellingham, Wash.) (2023)

Volumetric changes measured by longitudinal deformable image registration may yield imaging biomarkers to discriminate neoadjuvant treatment response in ill-defined tumors characteristic of PDAC. Registration-based biomarkers may help to overcome visual limits of radiographic evaluation to improve clinical outcome prediction and inform treatment selection.

Keyphrases

rectal cancer
lymph node
locally advanced
deep learning
high resolution
cross sectional
squamous cell carcinoma
machine learning
radiation therapy
photodynamic therapy
combination therapy
replacement therapy