A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer.

Jon PeñarandoLaura M López-SánchezRafael MenaSilvia Guil-LunaFrancisco CondeVanessa HernándezMarta ToledanoVictoria GudiñoMichela RaponiCaroline BillardCarlos VillarCésar DíazJosé Gómez-BarbadilloJuan De la Haba-RodríguezKevin MyantEnrique ArandaAntonio Rodríguez-Ariza

Published in: BMC biology (2018)

Our data support that eNOS upregulation occurs after Apc loss, emerging as an unexpected potential new target in poor-prognosis mesenchymal colorectal tumors, where NO scavenging could represent an interesting therapeutic alternative to targeting the CSC subpopulation.

Keyphrases

poor prognosis
nitric oxide synthase
stem cells
nitric oxide
long non coding rna
bone marrow
signaling pathway
electronic health record
endothelial cells
cell therapy
cancer therapy
big data
machine learning
cell proliferation
pi k akt
climate change