Cerebral artery overexpression of the NMUR1 gene is associated with moyamoya disease: a weighted gene co-expression network analysis.
Samuel D PetterssonShunsuke KogaShan AliAlejandro Enriquez-MarulandaPhilipp TausskyChristopher S OgilvyPublished in: Cerebrovascular diseases (Basel, Switzerland) (2024)
This is the first study to have performed WGCNA on samples directly affected by MMD. NMUR1 expression is well known to induce localized arterial smooth muscle constriction and recently, type 2 inflammation which can predispose to arterial stenosis potentially advancing the symptoms and progression of MMD. Further validation and functional studies are necessary to understand the precise role of NMUR1 upregulation in MMD and its potential implications.
Keyphrases
- network analysis
- poor prognosis
- smooth muscle
- cell proliferation
- genome wide
- copy number
- long non coding rna
- oxidative stress
- binding protein
- genome wide identification
- subarachnoid hemorrhage
- transcription factor
- signaling pathway
- computed tomography
- magnetic resonance imaging
- dna methylation
- physical activity
- brain injury
- contrast enhanced
- sleep quality
- genome wide analysis
- spinal cord
- cerebral ischemia